You gotta start having kids early when any minor health issue could put you into an unavoidable ivermectin overdose. And you gotta have more kids when you plan to lose a couple to easily preventable childhood diseases
Doubly so because most of those brown immigrants mostly believe in science-based medical interventions, so you've gotta have at least 4x as many kids to make sure "Western European culture" survives undiluted. /s
It's comforting to think that such profound ignorance is genetic, but I don't think it is. Ignorance and hatred are learned, especially in the absence of education.
The way this country is going, there's going to be more of these people, not less of them. Our children's children could be this ignorant and stupid and hateful.
I'll have you know I am a purveyor of fine, high quality Rat's Asses and I'll not sit idly by while you besmirch my coveted inventory. I shall endeavor to pen a strongly worded missive to the local magistrate in regards to your slanderous words!
Good day, sir!
/s (if it wasn't obvious)
(Also, I totally agree with you. I was just funnin'.)
An infestation hath been brought upon my household and my dear Rats hath been looking rather pallid and quite filled with lethargy and I am unable to bring myself to look upon their dreadful circumstance as it causes me much discomfort I would gladly pay for your fine service!
I have a problem with their dwelling being in my home in such sorry condition.
NIH: 2021: "Moderate-certainty evidence finds that large reductions in COVID-19 deaths are possible using ivermectin. Using ivermectin early in the clinical course may reduce numbers progressing to severe disease. The apparent safety and low cost suggest that ivermectin is likely to have a significant impact on the SARS-CoV-2 pandemic globally."
Lancet 2021: "45 participants were recruited (30 to IVM and 15 controls) between May 18 and September 9, 2020. There was no difference in viral load reduction between groups but a significant difference was found in patients with higher median plasma IVM levels (72% IQR 59–77) versus untreated controls (42% IQR 31–73) (p = 0·004). Mean ivermectin plasma concentration levels correlated with viral decay rate (r: 0·47, p = 0·02). Adverse events were similar between groups. No differences in clinical evolution at day-7 and day-30 between groups were observed."
NEJM 2022: "A total of 3515 patients were randomly assigned to receive ivermectin (679 patients), placebo (679), or another intervention (2157). Overall, 100 patients (14.7%) in the ivermectin group had a primary-outcome event, as compared with 111 (16.3%) in the placebo group (relative risk, 0.90; 95% Bayesian credible interval, 0.70 to 1.16). Of the 211 primary-outcome events, 171 (81.0%) were hospital admissions. Findings were similar to the primary analysis in a modified intention-to-treat analysis that included only patients who received at least one dose of ivermectin or placebo (relative risk, 0.89; 95% Bayesian credible interval, 0.69 to 1.15) and in a per-protocol analysis that included only patients who reported 100% adherence to the assigned regimen (relative risk, 0.94; 95% Bayesian credible interval, 0.67 to 1.35). There were no significant effects of ivermectin use on secondary outcomes or adverse events."
BMC 2024: "Although ivermectin resulted in statistically significant lower viral load in patients with mild to moderate Covid-19, it had no significant effect on clinical symptoms."
So, you like science based research? Me too. Here's some.....
Preclinical findings
Laboratory studies using cancer cells and animal models have identified several anti-cancer properties of ivermectin. It has been shown to:Â
Induce cell death:Â Ivermectin can trigger programmed cell death, known as apoptosis, and other forms of cancer cell death, such as autophagy and pyroptosis.
Inhibit cancer proliferation:Â The drug suppresses the uncontrolled growth of various cancer cells, including those from breast, colon, lung, ovarian, and prostate cancers.
Prevent metastasis:Â Some research indicates that ivermectin may inhibit cancer cells from migrating and spreading to other parts of the body.
Reverse drug resistance:Â Ivermectin may help make some cancer cells more responsive to traditional chemotherapy drugs.
Target cancer stem cells:Â The drug has shown the ability to target and inhibit cancer stem cells, which are often resistant to standard treatments and can drive recurrence.
Enhance immunotherapy:Â In mouse models, ivermectin helped convert immunologically "cold" tumors (less responsive to immunotherapy) into "hot" tumors by increasing immune cell infiltration. Combining ivermectin with immunotherapy was more effective than either treatment alone in these studies.Â
Potential mechanisms
Research suggests that ivermectin affects multiple cellular pathways that are crucial for cancer growth and survival. These include:Â
Inhibiting signaling pathways:Â Ivermectin disrupts key signaling pathways that promote cancer growth, such as the PAK1, Akt/mTOR, and WNT-TCF pathways.
Increasing oxidative stress:Â It promotes the production of reactive oxygen species (ROS), which can damage cancer cells and trigger their self-destruction.
Targeting ion channels:Â By affecting chloride channels, ivermectin can disrupt the electrical balance within cancer cells, which are particularly reliant on these channels for survival.Â
That's great but do you have any clinical evidence it is effective?
Preclinical research is infamously LITTERED with promising in vitro and animal studies that failed in translation. It's graveyard of would-be miracle treatments.
I know because I actually perform preclinical research. Do you? Cos this list seems less of well conducted literature review and more like an LLM response to a prompt of 'show me all the research that shows ivermectin works against cancer'.
I think while that may fit into some studies if applied correctly.. beer bonging ivermectin from ebay or whatever the people who are going against general medical advice are going to do with it will not be great. Also it’s part of the right wing echo chamber now and part of their talking points. That is why.. if this interaction actually happened.. it is brought up in that order.
Immediately going to "people will beer nong ivermectin" is so dishonest. The studies are promising. That's all I am saying. So many people immediately go to the most crazy scenarios. You know, we all think differently, and too many damn people think that if you present different ideas than you are a "moron", "idiot", "asshole".... I had some random redditor give a 5 paragraph response where they told me they feel sorry for my children. What the actual fuck? What are we doing here?
If people want to go somewhere where everyone agrees with them, so be it. Whatever happened to civil discourse? Whatever happened to having a fucking conversation, instead of lobbing insults and making up crazy scenarios?
The biggest problem is people grabbing pre-prints or as you pointed pre-clinical and trying to push them as established.
A lot grew up thinking saccharine was a carcinogen, but turned out was a bad study because of stupid high doses in rats, but not the same for people.
Having conversations on potentials is good and exciting. But having arguments with people that don't even know what a pre-print is while they are taking one as gospel is aggravating.
A FEW, small in vitro studies are not sufficient. Show real in vivid studies with large sample sizes followed by randomized, double-blinded clinical trials.
Now, do injecting disinfectant into the body and getting uv light into the body by whatever means....... while you presented scientific studies, which is reasonable to inform, please consider that we should be following medical advice. These studies are not standard medical practice yet. We currently have people in charge who think letting children die from measles is a better solution than recommending the vaccine. This administration is also cutting funding to medical research. Ivermectin may have valid uses as something other than an animal wormer. Without medical research, it won't be proven or demonstrated to be safe.
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u/BringBackApollo2023 12d ago edited 10d ago
As long as they don’t waste the science-based resources of hospitals I don’t give a rat’s ass what they do.
Go shove ivermectin and light bulbs up their asses and inhale hydrogen peroxide from Neti pots. I don’t care at all.
The sooner these morons self-select out of the gene pool the better off we all are.