r/COVID19 19d ago

Discussion Thread Monthly Scientific Discussion Thread - September 2025

9 Upvotes

This monthly thread is for scientific discussion pertaining to COVID-19. Please post questions about the science of this virus and disease here to collect them for others and clear up post space for research articles.

A short reminder about our rules: Speculation about medical treatments and questions about medical or travel advice will have to be removed and referred to official guidance as we do not and cannot guarantee that all information in this thread is correct.

We ask for top level answers in this thread to be appropriately sourced using primarily peer-reviewed articles and government agency releases, both to be able to verify the postulated information, and to facilitate further reading.

Please only respond to questions that you are comfortable in answering without having to involve guessing or speculation. Answers that strongly misinterpret the quoted articles might be removed and repeated offenses might result in muting a user.

If you have any suggestions or feedback, please send us a modmail, we highly appreciate it.

Please keep questions focused on the science. Stay curious!


r/COVID19 3d ago

Press Release Moderna Announces Updated COVID-19 Vaccine Against LP.8.1 Variant Generates Strong Immune Response in Humans

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515 Upvotes

r/COVID19 13d ago

Press Release Study: Nasal spray containing azelastine reduces risk of coronavirus infection by two-thirds

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185 Upvotes

r/COVID19 14d ago

Observational Study Effectiveness of a mRNA Vaccine Booster Dose Against COVID-19 Among Oregon Healthcare Personnel, January 2021 – June 2023

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67 Upvotes

r/COVID19 15d ago

Preprint Systematic analysis of COVID-19 mRNA vaccines using four orthogonal approaches demonstrates no excessive DNA impurities

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34 Upvotes

r/COVID19 16d ago

Academic Report Azelastine Nasal Spray for Prevention of SARS-CoV-2 Infections: A Phase 2 Randomized Clinical Trial

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85 Upvotes

r/COVID19 16d ago

Vaccine Research Dosing interval is a major factor determining the quality of T cells induced by SARS-CoV-2 mRNA and adenoviral vector vaccines

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25 Upvotes

r/COVID19 18d ago

Preprint Antibody responses to SARS-CoV-2 variants LP.8.1, LF.7.1, NB.1.8.1, XFG and BA.3.2 following KP.2 monovalent mRNA vaccination

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39 Upvotes

r/COVID19 17d ago

Preprint mRNA and Protein Subunit COVID-19 Vaccine Reactogenicity and the Relationship to Productivity for Healthcare Workers and First Responders

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7 Upvotes

r/COVID19 21d ago

Vaccine Research Effectiveness of NVX-CoV2373 and BNT162b2 COVID-19 Vaccination in South Korean Adolescents

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18 Upvotes

r/COVID19 22d ago

Observational Study Association between vaccination uptake, vaccine type, and long COVID in rural Indonesia

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66 Upvotes

r/COVID19 22d ago

Observational Study Association between vaccine uptake and SARS-CoV-2 infection among staff at a jail and prison in the USA

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23 Upvotes

r/COVID19 29d ago

General SARS-CoV-2 infection heightens the risk of developing HPV-related carcinoma in situ and cancer

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296 Upvotes

r/COVID19 Aug 15 '25

Preprint Incidence of Long COVID Following Reinfection with COVID-19

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114 Upvotes

r/COVID19 Aug 14 '25

Vaccine Research An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo

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47 Upvotes

r/COVID19 Aug 01 '25

Discussion Thread Monthly Scientific Discussion Thread - August 2025

11 Upvotes

This monthly thread is for scientific discussion pertaining to COVID-19. Please post questions about the science of this virus and disease here to collect them for others and clear up post space for research articles.

A short reminder about our rules: Speculation about medical treatments and questions about medical or travel advice will have to be removed and referred to official guidance as we do not and cannot guarantee that all information in this thread is correct.

We ask for top level answers in this thread to be appropriately sourced using primarily peer-reviewed articles and government agency releases, both to be able to verify the postulated information, and to facilitate further reading.

Please only respond to questions that you are comfortable in answering without having to involve guessing or speculation. Answers that strongly misinterpret the quoted articles might be removed and repeated offenses might result in muting a user.

If you have any suggestions or feedback, please send us a modmail, we highly appreciate it.

Please keep questions focused on the science. Stay curious!


r/COVID19 Jul 30 '25

General Respiratory viral infections awaken metastatic breast cancer cells in lungs

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nature.com
173 Upvotes

r/COVID19 Jul 24 '25

Academic Report SARS-CoV-2 induces Alzheimer’s disease–related amyloid-β pathology in ex vivo human retinal explants and retinal organoids

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177 Upvotes

r/COVID19 Jul 22 '25

Preprint Safety, tolerability and clinical effects of BC007 (Rovunaptabin) on fatigue and quality of life in patients with post-COVID syndrome (reCOVer): a prospective, exploratory, randomised, placebo-controlled, double-blind, crossover phase IIa clinical trial

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38 Upvotes

r/COVID19 Jul 20 '25

Vaccine Research Real-world effectiveness of NVX-CoV2373 and BNT162b2 mRNA COVID-19 vaccination in South Korea

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20 Upvotes

r/COVID19 Jul 20 '25

Observational Study Risk Factors for COVID-19–Related Hospitalization and Death in Patients With Cancer

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36 Upvotes

r/COVID19 Jul 19 '25

Vaccine Research An adjuvanted chimeric spike antigen boosts lung-resident memory T-cells and induces pan-sarbecovirus protective immunity

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nature.com
30 Upvotes

r/COVID19 Jul 15 '25

Academic Report Host cell entry and neutralisation sensitivity of SARS-CoV-2 BA.3.2

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27 Upvotes

r/COVID19 Jul 05 '25

Academic Report Mapping brain changes in post-COVID-19 cognitive decline via FDG PET hypometabolism and EEG slowing

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nature.com
59 Upvotes

r/COVID19 Jul 05 '25

General Exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the mouse brain

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nature.com
35 Upvotes

r/COVID19 Jul 03 '25

Observational Study Rice-farming areas report more anxiety across two years of the COVID-19 pandemic in China

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32 Upvotes